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Are all GIST tumors cancer? Gastrointestinal stromal tumors (GISTs) may be malignant (cancer) or benign (not cancer). They are most common in the stomach and small intestine but may be found anywhere in or near the GI tract. Some scientists believe that GISTs begin in cells called interstitial cells of Cajal (ICC), in the wall of the GI tract.
What causes gastrointestinal stromal tumor? A few families have gastrointestinal stromal tumors (GISTs) caused by a gene mutation passed down from parent to child. (See Gastrointestinal Stromal Tumor Risk Factors.) But most gene mutations related to GISTs are not inherited. These changes occur for no apparent reason, and are called acquired or sporadic.
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